Horizon Europe · Europäische Union

Phase 1 including first-in-human clinical trials to test biomarker-guided medicines or multi-modal treatment…

Full title in the source: Phase 1 including first-in-human clinical trials to test biomarker-guided medicines or multi-modal treatment interventions for patients with rare or very rare cancers or cancer subtypes

Öffnet am 10. Februar 2027

Das EU-Programm Horizon Europe plant 3 Förderungen mit 7 Mio. € – 9 Mio. € pro Projekt bei einem Gesamtbudget von 24 Mio. €. Die Einreichungsfrist endet am 16. September 2027 (EU-Ausschreibungen enden meist um 17:00 Uhr Brüsseler Zeit). Organisationen aus EU-Mitgliedstaaten und assoziierten Ländern wie der Türkei können in der Regel teilnehmen; maßgeblich sind die Bedingungen des Topics.

Frist: 16. September 2027 (in 305 Tagen)
Öffnet: 10. Februar 2027
Fördersumme: 7 Mio. € – 9 Mio. € pro Projekt
Gesamtbudget: 24 Mio. €
Förderquote: 100 % der förderfähigen Kosten Standardregel des Programms; die Ausschreibung kann abweichen.
Gesamtbudget: 24 Mio. €
Erwartete Förderungen: 3
Maßnahmentyp: HORIZON Research and Innovation Actions · HORIZON Lump Sum Grant
Wahrscheinliche Antragstellende: Unternehmen, KMU / Start-ups, Gemeinnützige, Hochschulen & Forschung, Öffentliche Stellen Aus Quellkategorien oder Programmregeln; maßgeblich ist die Ausschreibung.
Fördergeber: Horizon Europe (HORIZON)
Referenz: HORIZON-MISS-2027-02-CANCER-03
Ausschreibung: HORIZON-MISS-2027-02
Zuletzt geprüft: 14. November 2026

Offizielle Ausschreibung öffnen ↗ Frist zum Kalender hinzufügen

Die offiziellen Beschreibungen sind in der Sprache des Fördergebers (meist Englisch); Zusammenfassung und Eckdaten auf dieser Seite sind auf Deutsch.

Erwartete Ergebnisse

Proposals under this topic should aim to deliver results that are directed and tailored towards, and contribute to all of the following expected outcomes:

• Patients with rare or very rare cancers or cancer subtypes have access to tailored, promising biomarker-guided medicines or multi-modal treatment interventions via participation in subsequent clinical trials or national or regional compassionate use programmes by health authorities;

• Researchers, physicians, innovators [1] , startup, spin-off and spin-out companies, SMEs, charities or foundations and other professionals from different disciplines and sectors have access to innovative technology, medical devices or promising biomarker-guided medicines for further validation or commercialisation;

• National healthcare providers, policymakers and authorities in European regions, EU Member States and Associated Countries have early safety and efficacy evidence to support further testing of affordable biomarker-guided medicines or multi-modal treatment interventions that benefit patients with rare or very rare cancers in their healthcare systems;

Umfang

Patients with rare and very rare [2] cancers across EU Member States and Associated Countries often present with advanced disease due to late diagnosis and have access to few treatment options. Hence, these patients typically have a lower 5-year overall survival than those with more common cancers and face challenges with timely access to a small number of appropriate phase 1 clinical trials, despite good disease control rates [3] , to validate biomarker-guided medicines or multi-modal treatment interventions targeting their disease and adapted to an increasingly precision oncology healthcare landscape.

Proposals should address all the following:

• When still relevant and required, finalise the preclinical validation of promising [4] biomarker-guided drugs [5] , for rare or very rare cancer indications through in vivo and/or ex vivo and/or in silico research models. Drug repurposing should be considered [6] . Data should be disaggregated by tumour biology, sex, gender, age and other relevant variables, such as by measures of socio-economic status or ethnicity;

Vollständigen Text lesen

• Validate early safety and efficacy of innovative medicines or as part of multi-modal treatment interventions in phase 1, including in first-in-human, multi-centre clinical trials, considering new trial designs [7] , for and with patients with rare or very rare cancers and their caregivers/families;

• The primary and secondary endpoints of the clinical trial(s) should support safety, efficacy and patient-reported outcomes. Such endpoints should be defined together with patients and their caregivers through research that stimulates social innovation and supports end-user engagement using participative research models.

• All datasets produced should be described with metadata records in the EU dataset catalogue of the European Health Data Space, while all tools and models should take advantage of current European research infrastructures, should follow the principles of open science and made available through the future UNCAN.eu platform;

• Applicants should include proof of advice from regulators on the design of the clinical trial(s), include an appropriate mix of stakeholders from various disciplines, and regional as well as national health authorities, and provide details of the clinical study(ies) in the dedicated annex using the template provided in the submission system;

Successful proposals will be asked to join the 'Diagnosis and treatment” cluster for the EU Cancer Mission [8] and should include a budget for networking, attendance at meetings, and joint activities [9] . The Commission will facilitate coordination of these activities.

The successful proposals are expected to build on resources made available by the Knowledge Centre on Cancer (KCC) [10] to foster EU alignment and coordination.

[1] Innovators turn research results into new and better services and products, to remain competitive in a global marketplace and to improve the quality of life of Europe’s citizens.

[2] ~24%…

Wer kann sich bewerben?

Consortium of at least 3 independent legal entities from 3 different EU Member States or associated countries, at least one in a Member State (Horizon Europe standard rule).

Antragstellerkategorien sind nur ein Ausgangspunkt. Über die Antragsberechtigung entscheidet die offizielle Ausschreibung.

Themen

Anticancer therapy Biophotonics, Imaging, image and data processing Cancer and its biological basis Quality-of-life Radiation therapy Surgery Tomography Clinical Research Common Cancers High Income Countries Oncology Nurses Precision Oncology Tumour Boards Twinning Widening Countries

Zeitplan

Single-stage call. Next deadline 2027-09-16. The portal states the exact cut-off time (EU calls usually close at 17:00 Brussels time).

So bewerben Sie sich

Lesen Sie das vollständige Topic im Portal: erwartete Ergebnisse, Umfang, Maßnahmentyp und die Teilnahmebedingungen einschließlich Länder- oder Konsortialvorgaben.
Registrieren Sie jede Partnerorganisation im EU Funding & Tenders Portal, um einen PIC zu erhalten.
Verbundprojekte in Forschung und Innovation benötigen in der Regel mindestens drei unabhängige Partner aus drei verschiedenen EU-Mitgliedstaaten oder assoziierten Ländern. Prüfen Sie die Regel für dieses Topic.
Bereiten Sie Teil A (Verwaltungsformulare und Budget im Portal) und Teil B (technische Beschreibung auf der offiziellen Vorlage für diesen Maßnahmentyp) vor.
Reichen Sie vor dem Fristende am Stichtag im Portal ein. Verspätete Anträge werden nicht angenommen.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.
Where applicants must be based: Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.
Where to apply: Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.

EU-Leitfaden zur Antragstellung lesen

Offizielle Quellen

Offizielle Ausschreibungsseite

Die Angaben auf dieser Seite stammen aus der offiziellen Quelle und wurden zuletzt am 14. November 2026 geprüft. Maßgeblich sind immer die Unterlagen des Fördergebers einschließlich späterer Änderungen.