National Institutes of Health · United States

High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)

Open

Applications close on 6 Mar 2027. Eligible applicant types include small businesses, public and State controlled institutions of higher education, nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education and 12 more.

Deadline: 6 Mar 2027 (in 111 days)
Grant amount: Not stated — see the official call
Funding rate: No mandatory cost sharing stated; funding percentage not stated
Cost sharing: Not required
Likely applicant types: SMEs / start-ups, Companies, Universities & research, Non-profits, Public bodies From source categories or programme rules; the call decides.
Funder: National Institutes of Health
Reference: RFA-DA-25-024
Assistance listing: 93.279 Drug Abuse and Addiction Research Programs
Last checked: 13 Nov 2026

Open the official call ↗ Add deadline to calendar

About this call

The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.

Who can apply

Small businesses
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
Special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Native American tribal governments (Federally recognized)
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
County governments
For profit organizations other than small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Applicant categories are a starting point. The official call decides eligibility.

Topics

Education Health

How to apply

Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Not stated in the call text we hold — check the official page
Where applicants must be based: Not stated in the call text we hold — check the official page
Where to apply: Not stated in the call text we hold — check the official page

Contact

National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

Where these facts come from

Fact	Value	How we know	Taken from the source
Deadline	6 March 2027	official data field	15 Nov 2026
Amount per applicant	Unknown — not stated in the source we hold	unknown	—
Total budget	Unknown — not stated in the source we hold	unknown	—
Funding rate	No mandatory cost sharing stated; funding percentage not stated	read from the official text	15 Nov 2026
Who can apply	Small businesses; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal…	official data field	15 Nov 2026
Where to apply	Unknown — not stated in the source we hold	unknown	—

Official sources

Official call page · Funder's programme page

Facts on this page come from the funder’s official data, taken on 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.