National Institutes of Health · United States

Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

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National Institutes of Health expects to make awards of up to $150,000 each, from a total budget of $150,000. Applications close on 11 Aug 2027. Eligible applicant types include city or township governments, native American tribal governments (Federally recognized), others (see text field entitled "Additional Information on Eligibility" for clarification) and 12 more.

Deadline: 11 Aug 2027 (in 269 days)
Grant amount: Up to $150,000 per project
Funding rate: No mandatory cost sharing stated; funding percentage not stated
Total budget: $150,000
Cost sharing: Not required
Likely applicant types: Public bodies, SMEs / start-ups, Companies, Universities & research, Non-profits From source categories or programme rules; the call decides.
Funder: National Institutes of Health
Reference: PAR-25-101
Assistance listing: 93.279 Drug Use and Addiction Research Programs
Last checked: 13 Nov 2026

Open the official call ↗ Add deadline to calendar

About this call

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

Who can apply

City or township governments
Native American tribal governments (Federally recognized)
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Small businesses
State governments
Private institutions of higher education
Special district governments
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Native American tribal organizations (other than Federally recognized tribal governments)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Applicant categories are a starting point. The official call decides eligibility.

Topics

Education Health

How to apply

Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Not stated in the call text we hold — check the official page
Where applicants must be based: Not stated in the call text we hold — check the official page
Where to apply: Not stated in the call text we hold — check the official page

Contact

National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

Where these facts come from

Fact	Value	How we know	Taken from the source
Deadline	11 August 2027	official data field	15 Nov 2026
Amount per applicant	Up to $150,000	official data field	15 Nov 2026
Total budget	$150,000	official data field	15 Nov 2026
Funding rate	No mandatory cost sharing stated; funding percentage not stated	read from the official text	15 Nov 2026
Who can apply	City or township governments; Native American tribal governments (Federally recognized); Others (see text field entitled "Additional Information on Eligibility" for clarification); Small businesses; State governments;…	official data field	15 Nov 2026
Where to apply	Unknown — not stated in the source we hold	unknown	—

Official sources

Official call page · Funder's programme page

Facts on this page come from the official source and were last checked 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.