National Institutes of Health · United States

HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

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National Institutes of Health expects to make awards of up to $375,000 each. Applications close on 23 Nov 2026. Eligible applicant types include others (see text field entitled "Additional Information on Eligibility" for clarification), private institutions of higher education and public and State controlled institutions of higher education.

Deadline: 23 Nov 2026 (in 8 days)
Grant amount: Up to $375,000 per project
Funding rate: No mandatory cost sharing stated; funding percentage not stated
Cost sharing: Not required
Likely applicant types: Universities & research From source categories or programme rules; the call decides.
Funder: National Institutes of Health
Reference: RFA-AT-25-003
Assistance listing: 93.121 Oral Diseases and Disorders Research; 93.213 Research and Training in Complementary and Integrative Health; 93.273 Alcohol Research Programs; 93.846 Arthritis, Musculoskeletal and Skin Diseases Research; 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders; 93.865 Child Health and Human Development Extramural Research; 93.866 Aging Research
Last checked: 13 Nov 2026

Open the official call ↗ Add deadline to calendar

About this call

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

Who can apply

Others (see text field entitled "Additional Information on Eligibility" for clarification)
Private institutions of higher education
Public and State controlled institutions of higher education

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Applicant categories are a starting point. The official call decides eligibility.

Topics

Health Income Security and Social Services

How to apply

Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Not stated in the call text we hold — check the official page
Where applicants must be based: Not stated in the call text we hold — check the official page
Where to apply: Not stated in the call text we hold — check the official page

Contact

National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

Where these facts come from

Fact	Value	How we know	Taken from the source
Deadline	23 November 2026	official data field	15 Nov 2026
Amount per applicant	Up to $375,000	official data field	15 Nov 2026
Total budget	Unknown — not stated in the source we hold	unknown	—
Funding rate	No mandatory cost sharing stated; funding percentage not stated	read from the official text	15 Nov 2026
Who can apply	Others (see text field entitled "Additional Information on Eligibility" for clarification); Private institutions of higher education; Public and State controlled institutions of higher education	official data field	15 Nov 2026
Where to apply	Unknown — not stated in the source we hold	unknown	—

Official sources

Official call page · Funder's programme page

Facts on this page come from the funder’s official data, taken on 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.