National Institutes of Health · United States

Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)

Full title in the source: Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)

Open

National Institutes of Health expects to make awards of up to $125,000 each. Applications close on 7 Sep 2028. Eligible applicant types include public and State controlled institutions of higher education and private institutions of higher education.

Deadline: 7 Sep 2028 (in 662 days)
Grant amount: Up to $125,000 per project
Funding rate: No mandatory cost sharing stated; funding percentage not stated
Cost sharing: Not required
Likely applicant types: Universities & research From source categories or programme rules; the call decides.
Funder: National Institutes of Health
Reference: PAR-25-415
Assistance listing: 93.113 Environmental Health; 93.121 Oral Diseases and Disorders Research; 93.172 Human Genome Research; 93.173 Research Related to Deafness and Communication Disorders; 93.242 Mental Health Research Grants; 93.273 Alcohol Research Programs; 93.279 Drug Use and Addiction Research Programs; 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health; 93.307 Minority Health and Health Disparities Research; 93.361 Nursing Research; 93.398 Cancer Research Manpower; 93.846 Arthritis, Musculoskeletal and Skin Diseases Research; 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research; 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders; 93.855 Allergy and Infectious Diseases Research; 93.859 Biomedical Research and Research Training; 93.865 Child Health and Human Development Extramural Research; 93.866 Aging Research; 93.867 Vision Research; 93.879 Medical Library Assistance
Last checked: 13 Nov 2026

Open the official call ↗ Add deadline to calendar

About this call

The SuRE program supports research capacity building at eligible higher education institutions through funding investigator-initiated biomedical research inbasic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH.

The purpose of SuRE-First awards is to provide support for investigator-initiated research at resource-limited institutions by full-time faculty who have not had any prior independent, peer-reviewed, external research grants, to furnish students with high-quality undergraduate and/or graduate research experiences, and to enhance the institutional scientific research culture.

Who can apply

Public and State controlled institutions of higher education
Private institutions of higher education

Other Eligible Applicants include the following:

Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Applicant categories are a starting point. The official call decides eligibility.

Topics

Education Environment Food and Nutrition Health Income Security and Social Services

How to apply

Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Not stated in the call text we hold — check the official page
Where applicants must be based: Not stated in the call text we hold — check the official page
Where to apply: Not stated in the call text we hold — check the official page

Contact

National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

Where these facts come from

Fact	Value	How we know	Taken from the source
Deadline	7 September 2028	official data field	15 Nov 2026
Amount per applicant	Up to $125,000	official data field	15 Nov 2026
Total budget	Unknown — not stated in the source we hold	unknown	—
Funding rate	No mandatory cost sharing stated; funding percentage not stated	read from the official text	15 Nov 2026
Who can apply	Public and State controlled institutions of higher education; Private institutions of higher education	official data field	15 Nov 2026
Where to apply	Unknown — not stated in the source we hold	unknown	—

Official sources

Official call page · Funder's programme page

Facts on this page come from the funder’s official data, taken on 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.