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National Institutes of Health · United States

Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward… (DP1 Clinical Trial Optional)

Full title in the source: Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)

Open

Applications close on 25 Sep 2028. Eligible applicant types include special district governments, nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, public and State controlled institutions of higher education and 12 more.

About this call

The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder.

Who can apply

• Special district governments
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Public and State controlled institutions of higher education
• City or township governments
• Private institutions of higher education
• Native American tribal organizations (other than Federally recognized tribal governments)
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• State governments
• County governments
• Public housing authorities/Indian housing authorities
• Independent school districts
• For profit organizations other than small businesses
• Others (see text field entitled "Additional Information on Eligibility" for clarification)
• Small businesses
• Native American tribal governments (Federally recognized)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Applicant categories are a starting point. The official call decides eligibility.

Topics

Health

How to apply

1. Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
2. Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
3. For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
4. Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
5. Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply

Not stated in the call text we hold — check the official page

Company stage

Not stated in the call text we hold — check the official page

Single applicant or consortium

Not stated in the call text we hold — check the official page

Where applicants must be based

Not stated in the call text we hold — check the official page

Where to apply

Not stated in the call text we hold — check the official page

Contact

National Institutes of Health · nidagmbemail@nida.nih.gov · 301-402-2541

Where these facts come from

Official sources

Official call page

Facts on this page come from the funder’s official data, taken on 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.

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