NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical…
Full title in the source: NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
Open
Applications close on 5 Apr 2029. Eligible applicant types include small businesses.
Deadline
5 Apr 2029 (in 872 days)
Grant amount
Not stated — see the official call
Funding rate
Cost sharing required — see the notice for your share
Cost sharing
Required
Likely applicant types
SMEs / start-ups, Companies From source categories or programme rules; the call decides.
Funder
National Institutes of Health
Reference
PA-27-101
Assistance listing
93.233 National Center on Sleep Disorders Research; 93.242 Mental Health Research Grants; 93.273 Alcohol Research Programs; 93.307 Minority Health and Health Disparities Research; 93.313 NIH Office of Research on Women's Health; 93.350 National Center for Advancing Translational Sciences; 93.351 Research Infrastructure Programs; 93.393 Cancer Cause and Prevention Research; 93.394 Cancer Detection and Diagnosis Research; 93.395 Cancer Treatment Research; 93.837 Cardiovascular Diseases Research; 93.838 Lung Diseases Research; 93.839 Blood Diseases and Resources Research; 93.840 Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders; 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research; 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders; 93.855 Allergy and Infectious Diseases Research; 93.859 Biomedical Research and Research Training; 93.865 Child Health and Human Development Extramural Research; 93.866 Aging Research; 93.867 Vision Research
The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).
Who can apply
Small businesses
Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project. This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first six due dates following the expiration of their budget period. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Applicant categories are a starting point. The official call decides eligibility.
Topics
Health
How to apply
Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
Submit before the deadline and keep the tracking number. Check for amendments before you submit.
From the call text
Who can apply
Not stated in the call text we hold — check the official page
Company stage
Not stated in the call text we hold — check the official page
Single applicant or consortium
Not stated in the call text we hold — check the official page
Where applicants must be based
Not stated in the call text we hold — check the official page
Where to apply
Not stated in the call text we hold — check the official page
Facts on this page come from the funder’s official data, taken on 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.
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