National Institutes of Health · United States

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

Open

Applications close on 5 Mar 2027. Eligible applicant types include state governments, special district governments, public and State controlled institutions of higher education and 12 more.

Deadline: 5 Mar 2027 (in 110 days)
Grant amount: Not stated — see the official call
Funding rate: No mandatory cost sharing stated; funding percentage not stated
Cost sharing: Not required
Likely applicant types: Public bodies, Universities & research, Non-profits, SMEs / start-ups, Companies From source categories or programme rules; the call decides.
Funder: National Institutes of Health
Reference: PAR-27-081
Assistance listing: 93.242 Mental Health Research Grants; 93.279 Drug Use and Addiction Research Programs; 93.866 Aging Research; 93.867 Vision Research
Last checked: 13 Nov 2026

Open the official call ↗ Add deadline to calendar

About this call

The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.

Who can apply

State governments
Special district governments
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
Private institutions of higher education
City or township governments
For profit organizations other than small businesses
Independent school districts
County governments
Public housing authorities/Indian housing authorities
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Native American tribal governments (Federally recognized)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Applicant categories are a starting point. The official call decides eligibility.

Topics

Health

How to apply

Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Not stated in the call text we hold — check the official page
Where applicants must be based: Not stated in the call text we hold — check the official page
Where to apply: Not stated in the call text we hold — check the official page

Contact

National Institutes of Health · NIA-NOFO-Scientific@nih.gov · 301-402-2541

Where these facts come from

Fact	Value	How we know	Taken from the source
Deadline	5 March 2027	official data field	15 Nov 2026
Amount per applicant	Unknown — not stated in the source we hold	unknown	—
Total budget	Unknown — not stated in the source we hold	unknown	—
Funding rate	No mandatory cost sharing stated; funding percentage not stated	read from the official text	15 Nov 2026
Who can apply	State governments; Special district governments; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education;…	official data field	15 Nov 2026
Where to apply	Unknown — not stated in the source we hold	unknown	—

Official sources

Official call page

Facts on this page come from the funder’s official data, taken on 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.