U.S. National Science Foundation · United States

Engineering Biological and Biomedical Systems (EBBS)

Open

Eligible applicant types include unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility".

Deadline: Not published yet — check the official call
Grant amount: Not stated — see the official call
Funding rate: No mandatory cost sharing stated; funding percentage not stated
Cost sharing: Not required
Likely applicant types: Companies, SMEs / start-ups, Non-profits, Universities & research, Public bodies, Individuals From source categories or programme rules; the call decides.
Funder: U.S. National Science Foundation
Reference: PD-26-369Y
Assistance listing: 47.041 Engineering
Last checked: 13 Nov 2026

Open the official call ↗

About this call

The Engineering Biological and Biomedical Systems (EBBS) program expands our understanding of biological and physiological systems, and it helps improve human health. For U.S. leadership in biotechnology, the engineering of biology is required at every scale. Engineering is needed for sensing biomarkers to making proteins to restoring functions of the body. In EBBS, fundamental mechanistic insights are combined with experimental and computational techniques. This approach helps develop platforms, devices, organisms, tissues, and processes that bring new understanding and control of biological functions.

EBBS supports studies of mechanisms that drive the behavior of microbial populations and cells, and of therapeutic cells and tissues. This includes discovering the underlying engineering principles that are needed to capture the responses of biological systems and bioreactors. It also includes the creation of novel biosensing platforms and new optical imaging and modulation strategies. Research that enables the design of biological systems to sense and respond to novel stimuli is welcome. Similarly, projects leading to insight into tissue changes or injury, and to systems that imitate or restore the functions of tissues or organs are encouraged.

Read the full text

Projects that advance rehabilitation engineering through new theories and approaches are supported by the EBBS program. Fundamental engineering research driven by the needs of persons with disabilities is encouraged.

The EBBS program expands what is possible in biomanufacturing; research may advance biotechnology and/or health. EBBS research must enable improved biological processes, create novel biomedical technologies, or achieve new understanding of physiological or pathological processes.

EBBS does not support proposals with a main goal of drug design, drug delivery, or the development of animal models of disease. Using existing models for experimental testing and validation is acceptable. Projects that focus on testing and validating therapies are not supported. Clinical trials are not supported. Limited studies involving human volunteers may be supported if appropriate to the project objectives. Projects focused on commercialization are more appropriate for the NSF Directorate for Technology, Innovation, and Partnerships (TIP).

Partnerships: To speed discovery and innovation, NSF partners with federal agencies, industry, international groups, and others. Current opportunities are at NSF ENG Partnerships.

Who can apply

Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

Applicant categories are a starting point. The official call decides eligibility.

Topics

Science and Technology and other Research and Development

Timing

Proposals accepted anytime

How to apply

Apply through the funder’s official page (link below); it states the procedure, documents and deadline.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Not stated in the call text we hold — check the official page
Where applicants must be based: Not stated in the call text we hold — check the official page
Where to apply: Not stated in the call text we hold — check the official page

Contact

U.S. National Science Foundation · grantsgovsupport@nsf.gov · 703-292-4203

Official sources

Official call page · Funder's programme page

Facts on this page come from the official source and were last checked 13 Nov 2026. The funder's own documents, including later amendments, always take precedence.