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National Institutes of Health · United States

INCLUDE Project: Omics Phenotypes Related to Down Syndrome (X01 Clinical Trial Not Allowed)

Forecast — expected to open 15 Apr 2027

This is a forecast: the funder has announced the opportunity but it is not open yet; posting is expected around 15 Apr 2027 and the estimated deadline is 15 Jun 2027. Eligible applicant types include public and State controlled institutions of higher education, nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, state governments and 12 more.

About this call

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to submit samples to NIH INCLUDE Project-supported resources to generate a large volume of integrated genomic and multi-omics data that will facilitate discovery of the molecular mechanisms of health conditions related to Down syndrome. The resulting data, and associated clinical and phenotypic data, will become part of the INCLUDE Data Hub for sharing with the research community. No funding will be provided directly to applicants under this NOFO. Applicants are encouraged to propose omics assays of existing biospecimens collected from individuals with Down syndrome and controls.

Who can apply

• Public and State controlled institutions of higher education
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• State governments
• Independent school districts
• Native American tribal governments (Federally recognized)
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Native American tribal organizations (other than Federally recognized tribal governments)
• City or township governments
• Public housing authorities/Indian housing authorities
• Special district governments
• County governments
• Small businesses
• Private institutions of higher education
• For profit organizations other than small businesses
• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Applicant categories are a starting point. The official call decides eligibility.

Topics

Health

How to apply

1. Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
2. Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
3. For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
4. Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
5. Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply

Not stated in the call text we hold — check the official page

Company stage

Not stated in the call text we hold — check the official page

Single applicant or consortium

Not stated in the call text we hold — check the official page

Where applicants must be based

Not stated in the call text we hold — check the official page

Where to apply

Not stated in the call text we hold — check the official page

Contact

The INCLUDE Project · DownSyndromeINCLUDE@mail.nih.gov · Please contact via e-mail.

Where these facts come from

Official sources

Official call page

Facts on this page come from the funder’s official data, taken on 15 Nov 2026. The funder's own documents, including later amendments, always take precedence.

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