National Institutes of Health · United States

NIH Director's Transformative Research Award (R01 Clinical Trial Optional)

Forecast — expected to open 15 Mar 2027

This is a forecast: the funder has announced the opportunity but it is not open yet; posting is expected around 15 Mar 2027 and the estimated deadline is 3 Sep 2027. Eligible applicant types include county governments, special district governments, independent school districts and 12 more.

Deadline: Estimated 3 Sep 2027 (not yet confirmed)
Opens: 15 Mar 2027
Grant amount: Not stated — see the official call
Funding rate: No mandatory cost sharing stated; funding percentage not stated
Expected awards: 6
Cost sharing: Not required
Likely applicant types: Public bodies, Non-profits, Universities & research, SMEs / start-ups, Companies From source categories or programme rules; the call decides.
Funder: National Institutes of Health
Reference: RFA-RM-28-003
Assistance listing: 93.310 Trans-NIH Research Support
Last checked: 15 Nov 2026

Open the official call ↗

About this call

The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program .

Who can apply

County governments
Special district governments
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Public housing authorities/Indian housing authorities
State governments
Small businesses
Private institutions of higher education
City or township governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)

Applicant categories are a starting point. The official call decides eligibility.

Topics

Health

How to apply

Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply: Not stated in the call text we hold — check the official page
Company stage: Not stated in the call text we hold — check the official page
Single applicant or consortium: Not stated in the call text we hold — check the official page
Where applicants must be based: Not stated in the call text we hold — check the official page
Where to apply: Not stated in the call text we hold — check the official page

Contact

NIH Director's Transformative Research Award Program · Transformative_Awards@mail.nih.gov · Please contact via email.

Where these facts come from

Fact	Value	How we know	Taken from the source
Deadline	3 September 2027	official data field	15 Nov 2026
Amount per applicant	Unknown — not stated in the source we hold	unknown	—
Total budget	Unknown — not stated in the source we hold	unknown	—
Funding rate	No mandatory cost sharing stated; funding percentage not stated	read from the official text	15 Nov 2026
Who can apply	County governments; Special district governments; Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal organizations…	official data field	15 Nov 2026
Where to apply	Unknown — not stated in the source we hold	unknown	—

Official sources

Official call page

Facts on this page come from the funder’s official data, taken on 15 Nov 2026. The funder's own documents, including later amendments, always take precedence.