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National Institutes of Health · United States

Mechanistic Toxicology of METALS

Full title in the source: Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)

Forecast — expected to open 4 Dec 2026

National Institutes of Health expects to make 20 awards of $100,000 – $500,000 each, from a total budget of $15 million. This is a forecast: the funder has announced the opportunity but it is not open yet; posting is expected around 4 Dec 2026 and the estimated deadline is 5 Jan 2027. Eligible applicant types include special district governments, state governments, nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education and 12 more.

About this call

The purpose of this funding opportunity is to support mechanistic research to understand how exposure to metals and metal-containing compounds alters biological processes relevant to human health. Of particular interest are studies that elucidate the absorption, distribution, transport, cellular trafficking, biological interactions, and mechanisms of action of metals, including mechanisms through which metals may alter immune homeostasis, cross the placental barrier, or gain access to and affect the central nervous system. Studies may employ experimental models, new approach methodologies, computational approaches, or leverage human biospecimens where these approaches are used to address defined mechanistic hypotheses.

Who can apply

• Special district governments
• State governments
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• For profit organizations other than small businesses
• Native American tribal organizations (other than Federally recognized tribal governments)
• Private institutions of higher education
• Public housing authorities/Indian housing authorities
• County governments
• Public and State controlled institutions of higher education
• Small businesses
• Native American tribal governments (Federally recognized)
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Independent school districts
• City or township governments
• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Applicant categories are a starting point. The official call decides eligibility.

Topics

Health

How to apply

1. Read the full notice of funding opportunity (NOFO) linked from the official page: eligibility, cost sharing and evaluation criteria.
2. Make sure your organisation has an active SAM.gov registration and Unique Entity ID (UEI); registration can take several weeks.
3. For NIH: the organisation and the principal investigator also need eRA Commons accounts; applications are usually submitted through Grants.gov (for example with ASSIST).
4. Prepare the required forms, narrative, budget and attachments exactly as the NOFO specifies.
5. Submit before the deadline and keep the tracking number. Check for amendments before you submit.

From the call text

Who can apply

Not stated in the call text we hold — check the official page

Company stage

Not stated in the call text we hold — check the official page

Single applicant or consortium

Not stated in the call text we hold — check the official page

Where applicants must be based

Not stated in the call text we hold — check the official page

Where to apply

Not stated in the call text we hold — check the official page

Contact

NOFO.information@niehs.nih.gov · NOFO.information@niehs.nih.gov · Please contact via email.

Where these facts come from

Official sources

Official call page

Facts on this page come from the funder’s official data, taken on 15 Nov 2026. The funder's own documents, including later amendments, always take precedence.

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