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Horizon Europe · Europäische Union

Leveraging functional genomics to reveal novel targets for cancer treatment

Öffnet am 10. Februar 2027

Das EU-Programm Horizon Europe plant 4 Förderungen mit 7 Mio. € – 8 Mio. € pro Projekt bei einem Gesamtbudget von 32,32 Mio. €. Die Einreichungsfrist endet am 16. September 2027 (EU-Ausschreibungen enden meist um 17:00 Uhr Brüsseler Zeit). Organisationen aus EU-Mitgliedstaaten und assoziierten Ländern wie der Türkei können in der Regel teilnehmen; maßgeblich sind die Bedingungen des Topics.

Frist
16. September 2027 (in 305 Tagen)
Öffnet
10. Februar 2027
Fördersumme
7 Mio. € – 8 Mio. € pro Projekt
Gesamtbudget
32,32 Mio. €
Förderquote
100 % der förderfähigen Kosten Standardregel des Programms; die Ausschreibung kann abweichen.
Gesamtbudget
32,32 Mio. €
Erwartete Förderungen
4
Maßnahmentyp
HORIZON Research and Innovation Actions · HORIZON Action Grant Budget-Based
Wahrscheinliche Antragstellende
Unternehmen, KMU / Start-ups, Gemeinnützige, Hochschulen & Forschung, Öffentliche Stellen Aus Quellkategorien oder Programmregeln; maßgeblich ist die Ausschreibung.
Fördergeber
Horizon Europe (HORIZON)
Referenz
HORIZON-MISS-2027-02-CANCER-01
Ausschreibung
HORIZON-MISS-2027-02
Zuletzt geprüft
14. November 2026

Offizielle Ausschreibung öffnen ↗ Frist zum Kalender hinzufügen

Die offiziellen Beschreibungen sind in der Sprache des Fördergebers (meist Englisch); Zusammenfassung und Eckdaten auf dieser Seite sind auf Deutsch.

Erwartete Ergebnisse

Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:

• Researchers and health professionals gain a deeper understanding of the functional effects of tumour heterogeneity during cancer initiation and progression, supporting the identification of more precise and novel therapeutic targets.

• Researchers, health professionals and innovators benefit from improved knowledge and tools to support the discovery and development of next generation genomically-informed cancer treatments.

• Researchers, innovators, and professionals across disciplines and sectors contribute to the UNCAN.eu research data platform by ensuring data interoperability, and enabling sustainable access to newly developed digital tools and models for the analysis and management of multimodal clinical data.

Umfang

The proposed topic will contribute to the EU Cancer Mission objective of improving the understanding of cancer initiation and progression. Of particular interest for this topic are paediatric and adolescent cancers [1] , cancers with limited treatment options, refractory cancers, rare cancers or cancer types with low five-year survival rates. Proposals may include the design of exploratory mechanistic studies using longitudinal patient bio-samples, clinical proof-of-concept studies and/or observational and translational studies involving newly collected or existing data, as appropriate. Applicants are encouraged to leverage technological advances in functional genomics [2] and structural biology including but not limited to rapid gene sequencing, single-cell studies, spatial gene mapping, spatial transcriptomics, epigenetic profiling, liquid biopsies and functional precision oncology pipelines. The use of causal inference, computational modelling and/or artificial intelligence tools is encouraged for the collection, visualisation, analysis and management of large, complex, and heterogeneous data sets. Collaboration among different scientific disciplines, including healthcare professionals, is envisaged [3] .

Vollständigen Text lesen

Applicants should address all of the following activities:

• To identify and validate new targets for innovative therapeutic approaches, by developing experimental models [4] and technologies to access the functional effects of tumour temporal heterogeneity on disease initiation, progression and relapse.

• To investigate the mechanisms underlying the interply between the tumor’s dynamic multi-omics characteristics, its microenvironment and patient specific factors [5] during disease initiation and progression. This includes elucidating the mechanisms of adaptive resistance to therapies, utilizing clinical data where appropriate [6] .

• To apply state-of-the-art approaches, tools and models to integrate and analyse FAIR (Findable, Accessible, Interoperable, Reusable) multimodal longitudinal patient data. These digital assets should be made available through the UNCAN.eu research platform. All datasets produced should be described with metadata records in the EU dataset catalogue of the European Health Data Space. The involvement of existing ESFRI research infrastructures offering life science resources [7] including biobanking options should be appropriately reflected in the proposal workplan.

Advantage should be taken to the extent possible of data and experience gained under current large-scale initiatives such as: the European 1M+ Genomes [8] and the European Cancer Imaging initiative [9] and others as appropriate. Successful proposals are expected to establish appropriate collaborations with the project UNCAN-CONNECT that is implementing the UNCAN.eu research platform [10] .

Successful proposals will be asked to join the 'Understanding' project cluster of the Cancer Mission [11] and should include a budget for networking, attendance at…

Wer kann sich bewerben?

Consortium of at least 3 independent legal entities from 3 different EU Member States or associated countries, at least one in a Member State (Horizon Europe standard rule).

Antragstellerkategorien sind nur ein Ausgangspunkt. Über die Antragsberechtigung entscheidet die offizielle Ausschreibung.

Themen

Anticancer therapy Cancer and its biological basis Epigenetics and gene regulation Genomics, comparative genomics, functional genomics Cancer onset Cancer progression Functional Genomics Therapeutic targets

Zeitplan

Single-stage call. Next deadline 2027-09-16. The portal states the exact cut-off time (EU calls usually close at 17:00 Brussels time).

So bewerben Sie sich

  1. Lesen Sie das vollständige Topic im Portal: erwartete Ergebnisse, Umfang, Maßnahmentyp und die Teilnahmebedingungen einschließlich Länder- oder Konsortialvorgaben.
  2. Registrieren Sie jede Partnerorganisation im EU Funding & Tenders Portal, um einen PIC zu erhalten.
  3. Verbundprojekte in Forschung und Innovation benötigen in der Regel mindestens drei unabhängige Partner aus drei verschiedenen EU-Mitgliedstaaten oder assoziierten Ländern. Prüfen Sie die Regel für dieses Topic.
  4. Bereiten Sie Teil A (Verwaltungsformulare und Budget im Portal) und Teil B (technische Beschreibung auf der offiziellen Vorlage für diesen Maßnahmentyp) vor.
  5. Reichen Sie vor dem Fristende am Stichtag im Portal ein. Verspätete Anträge werden nicht angenommen.

From the call text

Who can apply
Not stated in the call text we hold — check the official page
Company stage
Not stated in the call text we hold — check the official page
Single applicant or consortium
Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.
Where applicants must be based
Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.
Where to apply
Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.

EU-Leitfaden zur Antragstellung lesen

Offizielle Quellen

Offizielle Ausschreibungsseite

Die Angaben auf dieser Seite stammen aus der offiziellen Quelle und wurden zuletzt am 14. November 2026 geprüft. Maßgeblich sind immer die Unterlagen des Fördergebers einschließlich späterer Änderungen.

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