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Horizon Europe · European Union

Integrating climate-related exposures into the human exposome and characterising its changes in response to…

Full title in the source: Integrating climate-related exposures into the human exposome and characterising its changes in response to climate change

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The EU's Horizon Europe programme expects to make 4 awards of €10 million – €11 million each, from a total budget of €45 million. Applications close on 17 Feb 2027 (EU calls usually close at 17:00 Brussels time). Organisations in EU member states and Horizon Europe associated countries such as Türkiye can usually take part; the topic conditions control.

Deadline
17 Feb 2027 (in 94 days)
Grant amount
€10 million – €11 million per project
Total budget
€45 million
Funding rate
100% of eligible costs Standard rule for this programme; the call can differ.
Total budget
€45 million
Expected awards
4
Type of action
HORIZON Research and Innovation Actions · HORIZON Action Grant Budget-Based
Likely applicant types
Companies, SMEs / start-ups, Non-profits, Universities & research, Public bodies From source categories or programme rules; the call decides.
Funder
Horizon Europe (HORIZON)
Reference
HORIZON-HLTH-2027-01-ENVHLTH-02
Call
HORIZON-HLTH-2027-01
Last checked
14 Nov 2026

Open the official call ↗ Add deadline to calendar

Expected outcome

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Living and working in a health-promoting environment”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to most of the following expected outcomes:

• Researchers, policymakers, healthcare practitioners and the public have a more comprehensive understanding of the human exposome and the interactions between climatic, environmental and socio-behavioural factors, supported by FAIR [1] data linking these exposures to disease and health outcomes.

• Researchers, governments, policymakers, social care services and healthcare practitioners have improved knowledge on the links between the climatic, social, lifestyle and environmental factors of the exposome and global health burden, supporting their efforts to adopt the exposome approach to identify and address relevant health impacts.

Read the full text

• The public has access to the latest information on the influence of global environmental exposures on health, enabling the adoption of health-promoting, climate-resilient and nature-positive behaviours.

Scope

The exposome is the totality of exposures (and their interactions) experienced by an individual throughout their lifetime, including chemical, physical, biological, nutritional and psychosocial factors, from conception onwards. Many of these factors originate in the environment, including climate-related exposures such as extreme heat, heightened air pollution or drought. Climate change may amplify or interact synergistically with other better-established exposures, dynamically altering the human exposome and its health implications. Despite this, climate factors remain underrepresented in large-scale human exposome studies.

Research activities under this topic should strengthen the use of the exposome approach to study global exposures and generate evidence on their health implications. Proposals should focus on integrating climate-related factors into exposome research and understanding how the exposome changes in response to direct and indirect climate exposures. Moreover, research activities should be multiscale and multidisciplinary and account for the complexity and multifactorial nature of health determinants and the most pressing unmet medical needs in relation to environmental degradation and disrupted ecosystems. Proposals should include climate-relevant social determinants of health as part of their proposed activities.

Read the full text

More specifically, research actions under this topic should include all the following activities:

• Incorporate multiple climate exposures into exposomics studies and provide insights on their influence on disease burden, through interactions with other exposome factors.

• Predict, identify and monitor changes in the exposome (including environmental, social and occupational exposures) resulting from climate-related pressures and study their health implications to identify emerging health risks and potential benefits of climate change.

• Advance data generation, analysis, integration and interpretation in human exposomics, developing methodologies and integrating novel approaches (e.g. AI technologies and machine learning) for advanced data analytics, including for Real-World Data (RWD) [2] .

In addition, research actions should include several of the following targeted activities:

• Establish and investigate the biological pathways and mechanisms by which the exposome drives health impacts, jointly considering climate-related and other exposures. Build upon (when relevant) and study existing and/or newly generated longitudinal cohorts that combine individual exposome data with the corresponding medical, omics and biological data.

• Identify exposome-relevant indicators and biomarkers for exposome-related health risks and potential benefits using comprehensive exposome studies that combine climate, environmental, behavioural and social exposures. Account for disparities in individual trajectories and exposure patterns where relevant.

• Report on health-relevant exposome findings using, where possible, standardised…

Who can apply

Consortium of at least 3 independent legal entities from 3 different EU Member States or associated countries, at least one in a Member State (Horizon Europe standard rule).

Applicant categories are a starting point. The official call decides eligibility.

Topics

Cohort studies Disease determinants Environmental health Environmental risk measurement Environmental stressors Epidemiology Health determinants Health inequalities Health outcomes Health promotion Public and environmental health Public health Public health and epidemiology Risk assessment Risk factors Biodiversity Climate Exposome Health Pollution

Timing

Single-stage call. Next deadline 2027-02-17. The portal states the exact cut-off time (EU calls usually close at 17:00 Brussels time).

How to apply

  1. Read the full topic on the Funding & Tenders Portal: expected outcome, scope, type of action and the topic conditions, including any country restrictions.
  2. Register each participating organisation in the Funding & Tenders Portal to get a PIC.
  3. Consortium of at least 3 independent legal entities from 3 different EU Member States or associated countries (Horizon Europe standard rule; Türkiye is associated). Confirm in the topic conditions.
  4. Prepare Part A (administrative forms and budget, completed in the portal) and Part B (the technical description on the official template for this type of action).
  5. Submit in the portal before the cut-off time on the deadline day. Late submissions are not accepted.

From the call text

Who can apply
Not stated in the call text we hold — check the official page
Company stage
Not stated in the call text we hold — check the official page
Single applicant or consortium
Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.
Where applicants must be based
Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.
Where to apply
Read the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.

Read the EU application guide

Where these facts come from

FactValueHow we knowTaken from the source
Deadline17 February 2027
“Single-stage call. Next deadline 2027-02-17. The portal states the exact cut-off time (EU calls usually close at 17:00 Brussels time).”
official data field15 Nov 2026
Amount per applicantUnknown — not stated in the source we holdunknown—
Total budget€45 millionofficial data field15 Nov 2026
Funding rate100% of eligible costsprogramme standard rule15 Nov 2026
Who can applyConsortium of at least 3 independent legal entities from 3 different EU Member States or associated countries, at least one in a Member State (Horizon Europe standard rule).programme standard rule15 Nov 2026
Where to applyRead the topic conditions on the EU Funding & Tenders Portal for eligible countries, consortium requirements, budget and the application route.read from the official text15 Nov 2026

Official sources

Official call page

Facts on this page come from the funder’s official data, taken on 14 Nov 2026. The funder's own documents, including later amendments, always take precedence.

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